Spontaneous Disseminating Mammary Adenocarcinoma in a CD-1 Mouse
نویسندگان
چکیده
منابع مشابه
mouse spontaneous mammary adenocarcinoma as a suitable model of breast cancer in iran
background : breast cancer is a complicated disease and has various clinical manifestations and prognosis. the aim of this study is to make a breast cancer model suitable for basic, preclinical and clinical studies. materials and methods: five virgin bulb/c mice aged 6 weeks and spontaneous murine mammary adenocarcinoma cells (mmac) were used. after anesthesia induction, 1-3 million of mmacs we...
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We report a female Crlj:CD1(ICR) mouse with a spontaneous mammary gland tumor composed of biphasic tumor cells, i.e., epithelioid and spindle-shaped myoepithelial cells. Macroscopically, a subcutaneous mass, approximately 3 cm in diameter was found in the lumbodorsal region. Histopathologically, the epithelioid cells proliferated in an alveolar or nest-like growth pattern, occasionally forming ...
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A transgenic mouse model was used to evaluate the effect of endostatin treatment on spontaneous tumorigenesis. In this model system, female mice develop multiple mammary adenocarcinomas and male mice develop prostate cancer. Female mice treated with mouse endostatin during a 12-15-week period showed delayed tumor development by 4-6 weeks and significantly decreased tumor burden. Furthermore, en...
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A lung bioassay method was developed that demon strated that mammary adenocarcinomas appearing sponta neously in BALB/c x DBA/8F, female mice, as well as first-generation transplants of the tumors, gave rise to secondary pulmonary tumors. In a population of 122 mice bearing spontaneous tumors, the incidence of lung métas tases was found to correlate with the size of the primary tumor. The inci...
متن کاملActivity and Ultrastructure of Mitochondria from Mouse Mammary Gland and Mammary Adenocarcinoma 1
Mitochondria isolated from normal mammary glands taken from lactating and nonlactating C3H mice were compared with those isolated from mammary adenocarcinomas. Functional mitochondria could be obtained from the normal mammary glands only when milk was not present in the tissue prior to homogenization and when bovine serum albumin was added to the isolation medium. Albumin also protected tumor m...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1990
ISSN: 0192-6233,1533-1601
DOI: 10.1177/01926233900184p207